Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light [An article from Free

Author: X. Zhang
Edition:
Binding: Digital
ISBN: B000PDTBYS

Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light [An article from: DNA Repair]

This digital document is a journal article from DNA Repair, published by Elsevier in 2007. Get Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light [An article from diet books 2013 for free.
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Description:
The therapeutic effect of the thiopurines, 6-thioguanine (6-TG), 6-mercaptopurine, and its prodrug azathioprine, depends on the incorporation of 6-TG into cellular DNA. Unlike normal DNA bases, 6-TG absorbs UVA radiation, and UVA-mediated photochemical damage of DNA 6-TG has potentially harmful side effects. When free 6-TG is UVA irradiated in solution in the presence of molecular oxygen, reactive oxygen species are generated and 6-TG is oxidized to guanine-6-sulfonate Check Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light [An article from our best diet books for 2013. All books are available in pdf format and downloadable from rapidshare, 4shared, and mediafire.